What Is Pyridine-4-boronic Acid CAS 1692-15-5? Properties, Uses, and Supply Information

Pyridine-4-boronic acid, identified by CAS 1692-15-5, is a heteroaryl boronic acid used mainly as a building block in organic synthesis. Its commonly represented molecular formula is C₅H₆BNO₂, and its molecular weight is approximately 122.92 g/mol. At Maison Chemical, we regard it as a useful intermediate for coupling chemistry, medicinal chemistry, and research programs that require a pyridine ring and a reactive boronic acid group in the same molecule.

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The compound contains a boronic acid group at the 4-position of a pyridine ring. This combination gives it two important features: the pyridine nitrogen can participate in coordination and electronic interactions, while the boronic acid functionality can be used in carbon–carbon bond-forming reactions such as Suzuki–Miyaura coupling. Its exact performance depends on reaction design, water content, catalyst system, storage history, and the quality requirements of the buyer.

Core Identity and Chemical Function

What the Structure Means

Pyridine-4-boronic acid is also described as 4-pyridylboronic acid or pyridin-4-ylboronic acid. The pyridine ring is an aromatic, nitrogen-containing heterocycle, and the boronic acid group is attached opposite the ring nitrogen at the 4-position. This structure makes the material relevant when a synthetic route needs to introduce a pyridyl fragment into a more complex molecule.

In a typical cross-coupling concept, the boronic acid group acts as the transferable organic partner and reacts with a suitable halide or related electrophile in the presence of an appropriate catalyst and base. The final outcome is not determined by the starting material alone; solvent, catalyst loading, temperature, base, atmosphere, and purification conditions must be established by the chemist for each substrate.

Key Properties of Pyridine-4-boronic Acid CAS 1692-15-5

The following identity data are useful for procurement, internal documentation, and structure confirmation. Physical descriptions can vary by batch, particle size, moisture exposure, and analytical method, so I recommend using the supplier’s current specification sheet and certificate of analysis for release decisions.

The material is generally handled as a solid research chemical, although the observed color and physical form should be confirmed against the relevant lot documentation. Boronic acids may be sensitive to prolonged exposure to moisture, heat, or unsuitable storage conditions. For that reason, I advise buyers to keep the container tightly closed, minimize unnecessary opening, and follow the applicable safety data sheet rather than relying on a generic storage assumption.

Core Functions and Common Uses

Suzuki–Miyaura and Related Coupling Chemistry

The primary use of Pyridine-4-boronic acid CAS 1692-15-5 is as a coupling intermediate. It can provide a pyridin-4-yl fragment for the preparation of biaryl, heteroaryl, and other carbon-linked structures when paired with a compatible reaction partner. Researchers commonly evaluate it in route development because the resulting pyridine ring can add useful polarity, coordination behavior, and structural diversity to a target molecule.

Medicinal and Discovery Chemistry

In pharmaceutical and agrochemical research, pyridine-containing fragments are frequently explored during structure–activity relationship studies. Pyridine-4-boronic acid can support the preparation of compound libraries in which the pyridyl group is introduced at a defined position. Whether it is suitable for a specific project depends on the target structure, functional-group tolerance, and the efficiency of the planned coupling route.

Advanced Intermediate Development

The compound may also be used in the synthesis of specialty organic intermediates, ligands, and materials-related research compounds. Its value is greatest when the buyer needs a commercially identifiable precursor rather than a custom-synthesized molecule at the early stage of route screening. For scale-up, I recommend confirming reaction reproducibility and impurity clearance before treating laboratory success as a manufacturing-ready process.

Material Options and Important Distinctions

Buyers should distinguish the free boronic acid from protected boronate esters. Pyridine-4-boronic acid is not interchangeable with a pyridine-4-boronic acid pinacol ester or another protected derivative, because these materials have different molecular weights, handling characteristics, impurity profiles, and reactivity in some conditions.

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The right option depends on the planned chemistry. The free acid may be selected when the process is already designed around direct boronic acid use, while a protected ester may be considered when improved handling or a different stability profile is required. I recommend comparing the exact CAS number, structure, assay basis, water content, and analytical data before approving an alternative.

Buyer Selection Factors

Identity, Assay, and Analytical Documentation

For B2B procurement, I suggest confirming the CAS number, molecular formula, lot number, assay method, appearance description, and applicable impurity limits. A current certificate of analysis should be available for the delivered batch, and the analytical method should be relevant to the buyer’s internal release procedure. Depending on the project, buyers may also request HPLC, NMR, water, residual solvent, or elemental analysis information.

Packaging and Storage Expectations

Packaging should protect the solid from avoidable moisture and contamination during storage and transport. The appropriate pack size depends on whether the material is being used for route screening, repeated medicinal chemistry, process development, or commercial manufacturing. I encourage buyers to specify their intended use and packaging preference during inquiry so that the supply proposal can be aligned with actual consumption.

Process Compatibility

A high-quality starting material does not remove the need for route-specific development. Buyers should assess catalyst compatibility, base selection, reaction concentration, temperature, mixing, and work-up conditions on their own substrates. As an illustrative planning reference, a chemist may begin a screening experiment at a 1.00 mmol substrate scale and test the boronic acid near 1.0 equivalent, but the optimized amount must be established experimentally.

Handling and Storage Considerations

I recommend reviewing the supplier SDS before opening the container and using suitable laboratory controls, including appropriate protective equipment, ventilation, and spill procedures. The product should be kept in a closed, clearly labeled container under the storage conditions specified for the supplied lot. Buyers should avoid transferring the material into unmarked containers or combining it with other chemicals without a documented compatibility assessment.

Because boronic acid intermediates can show variable stability under unfavorable conditions, repeated exposure to humid air, excessive heat, or long storage after opening should be avoided. If a project is sensitive to trace impurities or degradation, the buyer should establish an internal retest or release policy. Any change in appearance, assay, water content, or chromatographic profile should be investigated before use.

Maison Chemical Supply Support

At Maison Chemical, I support B2B buyers by matching Pyridine-4-boronic acid CAS 1692-15-5 with the technical and commercial requirements of their project. We can discuss required quantity, packaging, documentation, destination, and intended application before preparing a quotation. This approach helps distinguish a small research order from a process-development or recurring supply requirement.

Our supply discussion can include product identification, available specification information, lot documentation, packaging options, and shipping coordination. Availability and lead time depend on current inventory, order quantity, quality requirements, and destination, so I do not recommend relying on a generic delivery promise. Instead, provide the required quantity, target specification, and delivery location so the quotation can be checked against the actual order conditions.

Key Takeaways

• Pyridine-4-boronic acid CAS 1692-15-5 is a heteroaryl boronic acid and a source of the pyridin-4-yl fragment.
• Its commonly represented formula is C₅H₆BNO₂, with an approximate molecular weight of 122.92 g/mol.
• Its principal application is synthetic coupling chemistry, especially route development involving pyridine-containing structures.
• The free acid should not be treated as automatically equivalent to a protected boronate ester.
• Buyers should confirm identity, assay, impurity information, packaging, storage guidance, and lot-specific documentation.

Conclusion: Is Pyridine-4-boronic Acid CAS 1692-15-5 Right for Your Project?

Pyridine-4-boronic acid CAS 1692-15-5 is a practical starting material when your synthesis requires a pyridin-4-yl unit that can participate in a suitable boronic-acid coupling strategy. Its molecular identity and functional-group combination make it relevant to medicinal chemistry, specialty intermediates, and research-scale process development. However, final suitability must be confirmed through route-specific testing and current batch documentation.

As the next step, define your required quantity, target assay, documentation needs, packaging preference, and delivery destination. Send these details to Maison Chemical for a project-specific supply review and quotation. I can then help you evaluate whether the free boronic acid, a protected derivative, or another material option best fits your technical and sourcing objectives.

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