3-Carboxyphenylboronic Acid CAS 25487-66-5: Properties, Applications, and Sourcing Guide

3-Carboxyphenylboronic acid, CAS 25487-66-5, is an aromatic boronic acid that combines a boronic acid group and a carboxylic acid group on a benzene ring. Its molecular formula is C₇H₇BO₄, and its molecular weight is approximately 165.94 g/mol. Researchers and chemical manufacturers commonly consider it as a building block for cross-coupling chemistry and as a substrate for preparing more complex aromatic compounds. For procurement, I recommend confirming the required grade, analytical documentation, quantity, and delivery destination before requesting a quotation.

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Key Takeaways

• CAS 25487-66-5 identifies 3-carboxyphenylboronic acid, also described as 3-boronobenzoic acid.
• The molecule has two useful functional groups: a boronic acid group for boron-mediated transformations and a carboxylic acid group for further derivatization.
• Its suitability depends on the intended reaction, the required purity and handling controls, and the buyer’s documentation and delivery requirements.
• Price, minimum order quantity, and lead time should be confirmed for the requested quantity and destination rather than assumed from a general product description.

Who This Guide Is For

This guide is intended for procurement teams, process chemists, research organizations, and manufacturers evaluating 3-carboxyphenylboronic acid for a chemical project. It is relevant whether you are screening a reagent for an initial experiment or sourcing material for a defined production requirement. The information focuses on product identity, potential applications, supplier evaluation, and practical quotation preparation. It is not a substitute for a project-specific risk assessment or review of the product’s current safety documentation.

Basic Concept and Chemical Context

3-Carboxyphenylboronic acid is a substituted phenylboronic acid. In its name, “3-carboxy” indicates that the carboxylic acid substituent is positioned at the meta position relative to the boronic acid group on the aromatic ring. The product can also be referred to as 3-boronobenzoic acid, though buyers should use the CAS number and a structural identifier when confirming identity across catalogs or specifications.

Identity and Core Properties

The molecular formula and molecular weight are useful for identity checks, stoichiometric calculations, and comparing supplier documentation. They do not by themselves establish a particular commercial grade, purity, appearance, storage condition, or shelf life. Those details should be verified against the specification and safety documentation supplied for the offered lot. If your process has sensitive moisture or impurity limits, state them explicitly during the inquiry.

Applications and Application Matching

The boronic acid functionality makes this compound a potential reagent for Suzuki–Miyaura cross-coupling, a palladium-catalyzed method for forming carbon–carbon bonds between an organoboron reagent and a suitable coupling partner. The carboxylic acid group can provide an additional point for modification, for example through transformations that convert a carboxylic acid into an ester, amide, or other derivative. The exact reaction route depends on the coupling partner, catalyst system, solvent, and conditions selected by the project chemist.

Where Buyers May Consider It

• Organic synthesis: As an aromatic building block when a project needs to introduce a meta-carboxyl-substituted phenyl unit.
• Medicinal chemistry: As a starting material for preparing or modifying small-molecule intermediates, subject to the project’s synthesis and evaluation plan.
• Materials and chemical research: As a functionalized aromatic reagent for exploratory synthesis where both boronic acid and carboxylic acid chemistry may be useful.

These are potential use areas, not a guarantee that the material will perform identically across different processes. A buyer should evaluate the specific reaction using the intended partners and conditions, then define acceptance criteria based on the result. If an alternative positional isomer or protected derivative is being considered, check the substitution pattern carefully because it can change the structure and the outcome of downstream synthesis.

Selection Framework for Buyers

A useful procurement decision starts with the application rather than a price comparison alone. Define whether the material is for screening, method development, or a more controlled manufacturing step, since those uses may require different documentation and acceptance limits. Then confirm the chemical identity, intended quantity, delivery location, and any handling or packaging requirements. This information helps suppliers provide a quotation that is relevant to the actual project.

Specifications and Documentation to Confirm

1. Identity: Match the product name and CAS 25487-66-5, and request structural or analytical identification information appropriate to your purchasing process.
2. Purity and test method: Ask for the offered specification, the stated purity basis, and the analytical method used where available. Do not assume that two stated purity values are directly comparable without understanding their methods and basis.
3. Lot documentation: Confirm whether a certificate of analysis and safety data sheet are available for the offered material and whether documentation can be associated with the shipped lot.
4. Packaging and handling: Specify the requested pack size and any project-specific handling requirements. Review the supplier’s safety documentation before use, storage, or transfer.
5. Commercial details: Request pricing, minimum order quantity, lead time, shipping terms, and any applicable export or destination requirements for the quantity being considered.

Pricing, MOQ, and Lead Time

There is no single price or lead time that applies to every order of 3-carboxyphenylboronic acid. Quoted cost can depend on the requested quantity, specification, packaging, order timing, and delivery destination. Minimum order quantity may also vary with the product’s current supply arrangement and the requested pack size. Buyers should request a written quotation that identifies the material, quantity, documentation, and applicable commercial terms.

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For a time-sensitive project, ask the supplier to distinguish confirmed availability from an estimated dispatch or delivery schedule. If the material is not immediately available, request the expected sourcing or production timeline and clarify when that estimate will be reconfirmed. Avoid planning a critical synthesis around an unverified lead-time assumption. Where possible, allow time for incoming inspection and review of lot documents before the material is needed in the process.

Supplier Evaluation Checklist

A qualified supplier discussion should cover more than whether a product name appears on a catalog. Check that the supplier can confirm the chemical identity, provide relevant documentation, communicate the offered specification, and explain the basis for its delivery estimate. If your organization has qualification or change-control procedures, explain these requirements before placing an order. Clear communication at the inquiry stage can reduce avoidable delays and specification mismatches.

• Can the supplier confirm CAS 25487-66-5 and the requested product name?
• Can the supplier state the offered purity or other acceptance criteria and provide supporting lot documentation where available?
• Are pack size, packaging expectations, quotation validity, and delivery terms clearly stated?
• Can the supplier discuss export documentation or destination-specific requirements relevant to the shipment?
• Is there a clear contact for technical or order-related questions?

Common Sourcing Mistakes to Avoid

One frequent mistake is identifying the compound by name alone without checking the CAS number and substitution pattern. Another is treating a catalog purity value as a complete specification without asking about its test method, lot documentation, and acceptance basis. Buyers may also overlook practical details such as pack size, shipping destination, or whether the quoted lead time is confirmed. Recording these requirements in the purchase inquiry helps both the buyer and supplier assess the request consistently.

Do not assume that a supplier’s general product listing establishes stock status, a particular certification, or suitability for a regulated application. Request the documentation and commercial details that your own quality system requires, and review them before order placement. For process-critical use, evaluate the received lot under your organization’s incoming-material procedures. These steps support a more controlled sourcing decision without making unsupported assumptions about product performance.

Working with Maison Chemical

Maison Chemical supplies chemical products for B2B customers and can discuss sourcing requirements for 3-carboxyphenylboronic acid CAS 25487-66-5. When you contact us, include your target quantity, required specification or purity, destination, intended use category, and documentation needs. This allows our team to assess the request and respond with applicable availability, quotation, and shipping information. Product details and commercial terms should be confirmed for each inquiry.

Conclusion and Next Steps

3-Carboxyphenylboronic acid CAS 25487-66-5 is a functionalized aromatic boronic acid with a molecular weight of approximately 165.94 g/mol and potential value as a synthetic building block, particularly where a meta-carboxyl-substituted aryl unit is required. Its two functional groups offer routes for further chemistry, but suitability depends on the specific reaction and project specification. To move from evaluation to sourcing, confirm identity, purity requirements, documentation, quantity, packaging, and destination before comparing quotations.

For a sourcing inquiry, send Maison Chemical your required quantity, target specification, delivery location, and documentation expectations. We can then discuss the relevant supply information and commercial terms for your request. This approach gives your team a clearer basis for evaluating the material and planning the next step.